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子供の体の大きさに相対して左心室の質量を表現する新しい方法
Bethany J Foster1, Andrew S Mackie, Mark Mitsnefes
1Department of Pediatrics, Montreal Children's Hospital, Hospital, McGill University, Montreal, Quebec H3H 1P3, Canada. beth.foster@muhc.mcgill.ca
Circulation
|May 21, 2008
まとめ
左心室質量対身長センチル曲線は,左心室質量指数 (LVMI) を超えて,さまざまな参照集団で,左心室質量指数 (LVMI) を上回る,子供における左心室高縮症 (LVH) を診断するための安定した方法を提供します.
科学分野:
- ペディアトリック・カルディオロジー
- バイオメディカルエンジニアリング
- 成長と開発の成長と開発
背景:
- 子どもの左心室多動症 (LVH) は,通常,左心室質量指数 (LVMI) が95パーセントを超えると定義されます.
- 基準集団における身長分布に対するLVMIの依存は,特に身長が下がるにつれてLVMIが増加する小児において,変動性を導入する.
研究 の 目的:
- センチル曲線を用いた新しいLVMI質量対体量サイズ正常化方法の有効性を,従来のLVMI方法と比較するために.
- 異なる基準集団の身長分布におけるLVH分類の安定性と信頼性を評価する.
主な方法:
- 左心室の質量は,440人の健康な子供と239人のリスクのある子供でMモードエコーカルディオグラフィーで評価されました.
- LVMIが計算され,Cole lambda-mu-sigma法を使用してLV質量対高度センチル曲線が構築されました.
- リスクのある子供は,サンプル特有のLVMIパーセンチルと新しいセンチル曲線法の両方を用いてLVHに分類されました.
主要な成果:
- LV質量対身長センチル法では,基準グループの身長分布に関係なく,LVHのリスクのある子供の割合の一貫した推定が得られました.
- 対照的に,LVMIに基づくLVHの割合の推定値は,使用された特定の参照集団によって著しく変化しました.
- センチル曲線のアプローチは,多様な小児集団の間でLVHを分類する上でより大きな安定性を示しました.
結論:
- 左心室質量対身長センチル曲線は,小児の集団において,LV質量と体サイズを正常化するためのより堅牢で信頼性の高い方法を提供します.
- この新しいアプローチは,LVMIの限界を克服し,子供におけるLVHの安定した診断ツールを提供します.
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