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Updated: Jul 5, 2026

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
10:27

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta

Published on: December 5, 2019

プロテアソームサブユニットRpn13は,新しいユビキチン受容体である

Koraljka Husnjak1, Suzanne Elsasser, Naixia Zhang

  • 1Institute of Biochemistry II and Cluster of Excellence Macromolecular Complexes, Goethe University, Theodor-Stern-Kai 7, D-60590 Frankfurt (Main), Germany.

Nature
|May 24, 2008
PubMed
まとめ

研究者らは,ユビキチン鎖に結合する新しいプロテアソマル受容体Rpn13を特定しました. この発見は,選択的タンパク質分解におけるユビキチン受容体とデウビキチン化酵素の間の機能的リンクを明らかにしています.

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The Proteasome01:13

The Proteasome

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The Proteasome02:18

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Eukaryotic cells can degrade proteins through several pathways. One of the most important amongst these is the ubiquitin-proteasome pathway. It helps the cell eliminate the misfolded, damaged, or unwarranted cytoplasmic proteins in a highly specific manner.
In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
The Proteasome02:18

The Proteasome

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In this pathway, the target proteins are first tagged with small proteins called ubiquitin. A series of enzymes carry out the ubiquitination of the target proteins - E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and E3...
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