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Updated: Jul 5, 2026

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques
08:58

Characterization of Glycoproteins with the Immunoglobulin Fold by X-Ray Crystallography and Biophysical Techniques

Published on: July 5, 2018

双機能CD22リガンドは,B細胞上の免疫複合体の組み立てにおいて,マルチメア免疫グロブリンをタンパク質の支架として使用する

Mary K O'Reilly1, Brian E Collins, Shoufa Han

  • 1Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|May 29, 2008
PubMed
まとめ

研究者は,抗体スキャフォールドを使用してCD22 (B細胞のレギュレータ) を標的とする合成分子を開発しました. この方法は,B細胞に複合体を効率的に組み立て,B細胞の悪性腫瘍を標的とする可能性を示しています.

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