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Updated: May 12, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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IGFBP-4は,心臓形成に必要な正規のWnt信号伝達の阻害剤です

Weidong Zhu1, Ichiro Shiojima, Yuzuru Ito

  • 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.

Nature
|June 6, 2008
PubMed
まとめ

インスリン類似成長因子結合タンパク質4 (IGFBP-4) は,インスリン類似成長因子 (IGFs) に独立して心臓細胞の発達を促進します. それは,心筋形成の重要な経路であるWntシグナリングを阻害し,IGFとWntシグナリングの間の新しいリンクを明らかにします.

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