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関連する概念動画

Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic acids02:43

Nucleic acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
Nucleic Acids02:43

Nucleic Acids

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...
The DNA Helix01:07

The DNA Helix

Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
The DNA Helix01:16

The DNA Helix

Overview

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関連する実験動画

Updated: Jul 4, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

ミニマルの核酸の二重構造である.

Mark K Schlegel1, Lars-Oliver Essen, Eric Meggers

  • 1Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein Strasse, D-35043 Marburg, Germany.

Journal of the American Chemical Society
|June 6, 2008
PubMed
まとめ

この研究は,最小の核酸二重体の結晶構造を明らかにし,安定したワトソン・クリックのようなペアリングを示しています. 独特の螺旋状のリボン構造を特徴とし,中空のコアと広範囲な水害性相互作用があります.

科学分野:

  • バイオケミストリー バイオケミストリー
  • 構造生物学 構造生物学とは
  • 合成生物学 合成生物学とは

背景:

  • 核酸化学は,DNAとRNAを超えて,代替的なバックボーンを探求しています.
  • グアニン-核酸アナログ (GNA) は,前生物化学の可能性のある最小限の核酸アナログです.
  • GNAのデュプレックス安定性を理解することは,そのアプリケーションにとって極めて重要です.

研究 の 目的:

  • 8 メル (S) -GNA 二重複の結晶構造を決定するには.
  • GNAのデュプレックス安定性の構造的基礎を調査する.
  • GNAデュプレックス内の相互作用を探求する.

主な方法:

  • 構造を決定するために,X線結晶学を用いた.
  • 銅 (II) イオンによる異常 difraktion がフェッシングに使用されました.
  • ベースペアリングとバックボーン相互作用の分析.

主要な成果:

  • (S) - GNA複合体の結晶構造が解明され,反並列の鎖とワトソン・クリックのような塩基配列が明らかになった.
  • GNAデュプレックスは,A型およびB型DNAとは異なる,大きな空洞なコアを持つユニークな右手の螺旋リボン構造を採用しています.

さらに関連する動画

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

関連する実験動画

Last Updated: Jul 4, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

  • 核塩基と脊椎の間の広範囲なインターストランド水害性相互作用と異常なイントラストランド水害性相互作用が観察されました.

    • 結論:

    • 最小限の核酸のバックボーンは,安定したワトソン・クリックのような二重複形成をサポートすることができます.
    • GNA複合体の独特の構造は,水害性相互作用を含む,その安定性に寄与する.
    • GNAは,最小限の遺伝子システムと合成生物学にとって有望な候補である.