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モノメチルアルセニートは,グルココルチコイド受容体の結合部位においてZn2+と競合する

Anne M Spuches1, Dean E Wilcox

  • 1Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, USA.

Journal of the American Chemical Society
|June 6, 2008
PubMed
まとめ

モノメチルアルセニート (MMAIII) は,アルセニートとは異なり,グルココルチコイド受容体のDNA結合領域 (GR-DBD) から亜鉛イオンを移動させます. この障害は,受容体がDNAを結合する能力を低下させ,遺伝子調節に影響を与えます.

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