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Updated: May 11, 2026

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
06:40

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

基板を標的とするガンマ分泌酵素調節器

Thomas L Kukar1, Thomas B Ladd, Maralyssa A Bann

  • 1Department of Neuroscience, Mayo Clinic, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. kukar.thomas@mayo.edu

Nature
|June 13, 2008
PubMed
まとめ

小分子ガンマ分泌酵素調節器 (GSM) は,ガンマ分泌酵素複合体自体ではなく,アミロイド前駆タンパク質 (APP) とアミロイドベータを標的にします. この二重作用は,アルツハイマー病の治療にシネジスティックなアプローチを提供する可能性があります.

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Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase11:57

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