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Updated: Jul 4, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

バクテリアの小分子によるNF-kappaBシグナル伝達の破壊による遺伝子発現の調節

Vladimir V Kravchenko1, Gunnar F Kaufmann, John C Mathison

  • 1Department of Immunology and Microbial Sciences, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|June 21, 2008
PubMed
まとめ

細菌のN-(3-オクソ-ドデカノイル) ホモセリンラクトン (C12) は,哺乳類における核転写因子NF-kappaBの調節を選択的に阻害する. この細菌分子は免疫遺伝子を抑制し,Pseudomonas aeruginosaのような病原菌が持続的な感染を確立するのを助けます.

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