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Updated: Jul 4, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

ボラとキナーゼオーロラアが協力してキナーゼPlk1を活性化し,ミトーシスエントリーを制御する

Akiko Seki1, Judith A Coppinger, Chang-Young Jang

  • 1Department of Biological Sciences, Stanford University, Stanford, CA 94305-5020, USA.

Science (New York, N.Y.)
|June 21, 2008
PubMed
まとめ

ボラとオーロラA (Aur-A) は,G2-M細胞サイクル移行をシネギー的に制御する. ボラは,体細胞にミト細胞の侵入に不可欠なPolo型キナーゼ1 (Plk1) のAur-A媒介活性化を促進する.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

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Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells06:29

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells

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Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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