慢性腎疾患に起因する全因死亡率:台湾の462,293人の成人を対象とした前向きなコホート研究
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Chi Pang Wen1, Ting Yuan David Cheng, Min Kuang Tsai
1Center for Health Policy Research and Development, National Health Research Institutes, Zhunan, Taiwan. cwengood@nhri.org.tw
Lancet (London, England)
|July 1, 2008
まとめ
慢性腎臓病 (CKD) は,台湾の成人の11%以上に影響を与え,特に低社会経済的グループでは,著しく高い死亡リスクがあります. 球の濾過率と尿検査による早期発見は,早死率を低減し,この拡大する疫病と闘うために不可欠です.
科学分野:
- ネフロロジーはネフロロジーを用います.
- 公衆衛生は公衆衛生である.
- エピデミオロジー エピデミオロジー
背景:
- 慢性腎疾患 (CKD) と末期腎疾患 (ESRD) は,世界的に増加しています.
- すべてのCKD段階における包括的な死亡データがない.
- この研究では,台湾におけるCKDの罹患率,死亡リスク,および関連死亡率を評価した.
研究 の 目的:
- 台湾における全段階の慢性腎臓病 (CKD) の全国的な罹患率を決定する.
- CKDと全因および心血管疾患による死亡率との関連性を評価する.
- 慢性腎臓病に起因する死亡率の負担を定量化するために,特に社会経済的地位が低い集団で.
主な方法:
- 1994年からスクリーニングされた462,293人の成人を2006年12月31日まで分析した.
- CKDの診断は,小球膜の濾過率と尿中のタンパク質濃度を用いて行われた.
- 死亡率に対する危険比率を推定するために,コックス比例リスクモデルが使用されました.
主要な成果:
- 全国のCKDの罹患率は11.93%で,その状態を認識している人の3.54%しかいなかった.
- CKDの罹患率は,社会経済的地位が低いグループ (19.87%) で,高い地位のグループ (7.33%) と比較して,著しく高かった.
- 慢性腎臓病の個人は,全因死亡のリスクが83%高かった (HR1.83),心血管疾患による死亡リスクが100%高かった (HR2.00).
- 慢性腎臓病は,全国の死亡者数の10.3%を占め,社会経済的地位が低い集団における死亡者の17.5%を占めました.
- 中国の漢方薬の定期的な使用は,CKDを発症するリスクの20%増加と関連していました.
結論:
- 特に脆弱な集団におけるCKDに関連する高い罹患率と死亡率は,CKDを主要な公衆衛生上の懸念事項として強調しています.
- グローメルーラ濾過率と尿検査に関する公衆の意識を高めることは,CKDの早期発見に不可欠です.
- 早期発見と管理は,早死率を低減し,世界的なCKDの流行を緩和するために不可欠です.
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