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Updated: Jun 23, 2026

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
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細胞の成長,代謝,腫瘍発生におけるPI(3) K-p110βの重要な役割

Shidong Jia1, Zhenning Liu, Sen Zhang

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Nature
|July 3, 2008
PubMed
まとめ

フォスファディチルイノシトール-3-OHキナーゼβ (PI(3) Kββ) は,キナーゼ依存およびキナーゼ依存の役割が異なっている. そのキナーゼに依存する機能は,腫瘍学的変異に不可欠であり,がん治療の有望な標的である.

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