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Updated: Jul 4, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

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パルメロリドA アナログの化学合成と生物学的評価

K C Nicolaou1, Gulice Y C Leung, Dattatraya H Dethe

  • 1Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences(ICES), Agency for Science, Technology and Research (A*STAR), Singapore. kcn@scripps.edu

Journal of the American Chemical Society
|July 5, 2008
PubMed
まとめ

研究者は,海洋抗腫瘍化合物パルメロリドAの構造-活性関係 (SARs) を調査した.アナログ25は10倍の効能増加を示し,アナログ51は同効性を示し,将来の薬物開発を導く.

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