エボ・デボと拡大する進化的合成:形態学的進化の遺伝的理論
1Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin-Madison, Madison, WI 53706, USA. sbcarrol@wisc.edu
Cell
|July 11, 2008
まとめ
形態学的多様性は,遺伝子発現を変化させ,主にシス調節配列の変化によって進化する. この遺伝理論は,保存されたタンパク質とその規制ネットワークを改変することによって,進化が生物学的形態をどのように形作るか説明しています.
科学分野:
- 進化的発達生物学 進化的発達生物学
- 分子生物学は分子生物学である.
- 遺伝学 遺伝学とは
背景:
- 形態学的進化の遺伝的基礎を理解することは,長年の生物学的課題です.
- 形態学的多様性は,遺伝子配列とその機能の変化から生じる.
研究 の 目的:
- 形態学的進化の遺伝理論を導く8つの原則を概説する.
- この理論を支える,種の多様性に関する最近の研究をレビューする.
主な方法:
- 分子生物学と進化発達生物学から原理を派生する.
- 種の多様性に関する経験的研究のレビュー.
主要な成果:
- 形態学的進化の遺伝的理論が提案されている.
- 形は,保存されたタンパク質の発現を変えることで進化する.
- 発達遺伝子のシス調節配列の変異がこれらの変化を誘導する.
結論:
- 形態の進化は,主に遺伝子発現の変化によって引き起こされる.
- 重要な発達遺伝子のシス調節性突然変異は,形態学的進化の中心にある.
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