関連する実験動画

Updated: Apr 12, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

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c-Srcをその不活性化剤Cskによって認識するための構造的基礎

Nicholas M Levinson1, Markus A Seeliger, Philip A Cole

  • 1Department of Molecular and Cell Biology, Department of Chemistry, Howard Hughes Medical Institute, California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, CA 94720, USA.

Cell
|July 11, 2008
PubMed
まとめ

C末端Srcキナーゼ (Csk) は,特定のドッキングメカニズムを通じてSrcファミリーキナーゼを特異的に標的にします. 構造分析では,c-SrcのC端尾がCskの活性部位の縁に位置しており,Cskの基板特異性を説明しています.

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