低出生体重児における動脈細動の証拠
Paul Mitchell1, Gerald Liew, Elena Rochtchina
1Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Hawkesbury Rd, Westmead, New South Wales, Australia. paul_mitchell@wmi.usyd.edu.au
Circulation
|July 16, 2008
まとめ
低出生体重によって示される子宮内での不十分な成長は,小児における網膜動脈の狭窄と関連しています. この発見は,早期の成長が血管の発達に影響し,将来の心臓血管の健康に影響を及ぼす可能性があることを示唆しています.
科学分野:
- 小児の心血管健康について
- 健康と病気の発達の起源 (DOHaD)
背景:
- 心血管疾患のリスクは胎児の発達中に発生する可能性があります.
- 子宮内での成長が子供のマイクロ血管構造に与える影響は不明である.
研究 の 目的:
- 子どもにおける子宮内成長マーカーと網膜微血管キャリバーとの関連性を調査する.
- 子宮内での不十分な成長が狭い動脈管につながり,潜在的に高血圧との関連を説明するという仮説を検証する.
主な方法:
- オーストラリアのシドニーに住む6歳児1,369人を対象に実施した人口ベースの研究.
- 網膜の動脈と静脈の口径は,デジタル化された網膜写真でコンピュータによる測定法で測定したものです.
- 親の記録から得られた出生体重,身長,頭周長.
主要な成果:
- 低出生体重,より短い出生長,およびより小さな頭部周長が,より狭い網膜動脈動脈口径と有意に関連していました.
- 出産時の体重の1キログラムの減少は,多重な要因を調整して,動脈細管の2.3ミームの減少と相関する.
- 同じような関連性は,出産時の長さや頭部周長と動脈口径で発見されました.
結論:
- 子宮内での成長が悪い子どもは,網膜動脈管が狭くなっている.
- これらの発見は,子宮内での不良な成長がマイクロ血管構造の発達に負の影響を及ぼすという仮説を支持する.
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