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Antihypertensive Drugs: Vasodilators01:23

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ナトリウムニトロプロシドは,心筋リバスカライゼーション後の心房細動の発生率を低下させますか? : パイロット研究です.

Raif Cavolli1, Kaan Kaya, Alp Aslan

  • 1Department of Cardiovascular Surgery, Umut Heart Hospital, GMK Bulvari, Ozveren Sok. No. 17, Maltepe, 06570, Ankara, Turkey. raif.cavolli@gmail.com

Circulation
|July 16, 2008
PubMed
まとめ
この要約は機械生成です。

ナトリウムニトロプルシド (SNP) は,冠動脈バイパス移植 (CABG) の後の心房細動 (AF) の発生率と持続時間を有意に減少させた. この酸化窒素のドナーは,一般的な合併症である術後のAFの予防に有望であることが示されています.

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科学分野:

  • 心血管外科手術についてです.
  • 心臓麻酔学 アネステシオロジー
  • 薬理学 薬理学とは

背景:

  • 手術後の心房細動 (AF) は,冠動脈バイパス移植 (CABG) の後の頻繁な合併症です.
  • CABG後のAFは,患者の罹病率と死亡率の増加と関連しています.
  • 窒素酸化物 (NO) のドナーは,AFに対する潜在的な予防効果のために調査されています.

研究 の 目的:

  • NOドナーであるナトリウムニトロプロシド (SNP) のCABG後のAF予防における有効性を評価する.
  • 術後のAFに関連したSNPの発生率,持続時間,および炎症マーカーの影響を評価する.

主な方法:

  • 選択CABGを受ける100人の患者を対象とした前向き,ランダム化,プラセボ対照試験です.
  • 患者はリウォーミング期間中にSNP (0.5μg x kg- 1 x min- 1)) またはプラセボを投与された.
  • 手術後のAFはテレメトリでモニタリングされ,高感度C反応性タンパク質 (hs-CRP) レベルが測定されました.

主要な成果:

  • AFの発生率は,プラセボグループ (27%) (P=0.005) と比較して,SNPグループ (12%) で有意に低かった.
  • AFエピソードの持続時間は,対照群 (7.55±1.94時間) (P=0.023) と比較して,SNP群 (5.33±1.86時間) で著しく短かった.
  • 術後のhs-CRPレベルは,対照群で上昇し,AFは長期間の入院を伴う.

結論:

  • ナトリウムニトロプロシドの投与は,CABG後の術後の心房細動の発生率と持続時間を大幅に減少させます.
  • SNPは,心臓外科手術患者のAF予防のための潜在的な治療薬として役立つ可能性があります.
  • SNP.の抗AF特性を完全に解明するために,さらなる研究が必要である.