Caenorhabditis elegansにおけるコピュレーションプラグポリモルフィズムの分子基礎について
Michael F Palopoli1, Matthew V Rockman, Aye TinMaung
1Department of Biology, Bowdoin College, 6500 College Station, Brunswick, Maine 04011, USA. mpalopol@bowdoin.edu
Nature
|July 18, 2008
まとめ
男性のC. elegansの遺伝的多様性は,交尾プラグの沈着の違いを引き起こす. plg-1遺伝子のレトロトランポゾン挿入が,この特性を説明し,男性競争に影響を及ぼします.
科学分野:
- 進化生物学の進化生物学について
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- 遺伝的多様性は進化的変化を誘発し,その遺伝的基盤を重要な研究分野にしています.
- nematode Caenorhabditis elegans の天然の孤立種におけるフェノタイプの二型化は,コピュレーションプラグの存在または欠如を伴う.
- 交尾後の分泌物である交尾プラグは,その後のオス交尾の成功に影響を与えます.
研究 の 目的:
- Caenorhabditis elegansのコピュレーションプラグ二形態の遺伝的基盤を調査するために.
- 交配のプラグ形成に責任を負う遺伝子を特定し,男性の生殖行動におけるその役割.
主な方法:
- Caenorhabditis elegans.の天然の孤立種を比較した分析.
- 原因となる変異を特定するために,遺伝的マッピングとシーケンシングを行います.
- 男性体性性腺の分泌細胞における遺伝子発現分析.
主要な成果:
- コピュレーションプラグのポリモルフィズムの原因は,plg-1遺伝子にレトロトランポゾンが挿入されたことによる.
- plg-1遺伝子は,コピュレーションプラグの主要な成分であるムシンのようなタンパク質をコードします.
- plg-1機能の喪失は,コピュレータプラグの欠如をもたらし,他の明らかな現象的効果はありません.
結論:
- plg-1遺伝子は,Caenorhabditis elegansのコピュレーションプラグ形成に不可欠である.
- C. elegansにおけるヘルマフロディティズムの進化は,雄の競争に対するリラックスした選択による機能喪失変異の広がりを促進した可能性がある.
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