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Updated: May 2, 2026

Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae
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Quantitation and Analysis of the Formation of HO-Endonuclease Stimulated Chromosomal Translocations by Single-Strand Annealing in Saccharomyces cerevisiae

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Saccharomyces cerevisiae ATM オーソローグは,ブレイク誘発の染色体転位を抑制する

Kihoon Lee1, Yu Zhang, Sang Eun Lee

  • 1Department of Molecular Medicine and Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA.

Nature
|July 25, 2008
PubMed
まとめ

イーストのシステムでは,Tel1とSae2が,壊れたDNAの末端を劣化させることで,DNAの二重鎖の断裂が癌に関連した染色体転位を引き起こすのを防ぐことを明らかにしています. この経路は染色体の完全性を保ち,転位リスクを軽減します.

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