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Updated: Apr 15, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

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Epac2の構造は,循環型AMPアナログとRAP1Bとの複合体である

Holger Rehmann1, Ernesto Arias-Palomo, Michael A Hadders

  • 1Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. h.rehmann@UMCutrecht.nl

Nature
|July 29, 2008
PubMed
まとめ

cAMPによって活性化されるエパックタンパク質は,細胞結合とインスリン分泌を調節する. 構造分析により,cAMP結合がEpac2構造をどのように変化させ,Rapタンパク質の相互作用を可能にするかを明らかにした.

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