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関連する概念動画

Optimal Foraging00:48

Optimal Foraging

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How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.
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Epiphytes, Parasites, and Carnivores02:40

Epiphytes, Parasites, and Carnivores

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Plants often form mutualistic relationships with soil-dwelling fungi or bacteria to enhance their roots’ nutrient uptake ability. Root-colonizing fungi (e.g., mycorrhizae) increase a plant’s root surface area, which promotes nutrient absorption. While root-colonizing, nitrogen-fixing bacteria (e.g., rhizobia) convert atmospheric nitrogen (N2) into ammonia (NH3), making nitrogen available to plants for various biological functions. For example, nitrogen is essential for the...
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The Cell Cycle Control System02:11

The Cell Cycle Control System

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The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
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Positive Regulator Molecules02:39

Positive Regulator Molecules

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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Anaphase Promoting Complex00:50

Anaphase Promoting Complex

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The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
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Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

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サイクリン狩り

Peter K Jackson1

  • 1Genentech, Inc., Department of Cell Regulation, South San Francisco, CA 94080, USA. pjackson@gene.com

Cell
|July 30, 2008
PubMed
まとめ
この要約は機械生成です。

25年前に発見された重要なタンパク質であるサイクリンは,サイクリン依存キナーゼを活性化させ,細胞分裂を調節し,ミトーシスへの侵入を促します. この根本的な発見は,細胞サイクル研究に影響を及ぼし続けています.

科学分野:

  • 分子生物学は分子生物学である.
  • 細胞生物学 細胞生物学
  • バイオケミストリー バイオケミストリー

背景:

  • ティム・ハントが25年前にサイクリンを発見したのは,細胞循環の調節を理解する上で重要なマイルストーンとなった.
  • サイクリンは,細胞周期の進行を制御する重要な調節タンパク質です.
  • その振動は,細胞分裂の正確なタイミングに不可欠です.

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