SIRT1は,コア・クロック・コンポーネントのサーカディアン・ディアセチラゼです
William J Belden1, Jay C Dunlap
1Department of Genetics, Dartmouth Medical School, Hanover, NH 03755, USA.
Cell
|July 30, 2008
まとめ
シルカディアンリズムレギュレータであるヒストンアセチルトランスフェラーゼであるCLOCKは,ヒストン脱酸化酵素であるNAD依存酵素SIRT1と作用する. SIRT1は,CLOCKの活性に逆らって,細胞代謝と昼夜系に影響を及ぼします.
科学分野:
- 分子生物学は分子生物学である.
- クロノバイオロジー クロノバイオロジー
- バイオケミストリー バイオケミストリー
背景:
- 転写活性化剤のCLOCKは,多数の遺伝子の昼夜発現に不可欠である.
- CLOCKはヒストンアセチルトランスフェラーゼ活性を持ち,昼夜システム内の遺伝子転写を調節します.
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