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Updated: Jul 3, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

SIRT1は,PER2脱エチル化による昼夜時計の遺伝子発現を調節する

Gad Asher1, David Gatfield, Markus Stratmann

  • 1Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH-1211 Geneva-4, Switzerland.

Cell
|July 30, 2008
PubMed
まとめ

SIRT1は,タンパク質脱酸化酵素であり,昼夜リズム転写に不可欠です. CLOCK-BMAL1と相互作用し,PER2の分解を促進し,代謝を体と結びつけ,コアクロック遺伝子を調節する.

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In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

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