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Updated: Jul 3, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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アポリポプロテインCIIIは,高脂血症と血管内皮細胞機能障害を関連付けています

Akio Kawakami1, Mizuko Osaka, Mariko Tani

  • 1Department of Geriatrics and Vascular Medicine, Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan. kawakami.vasc@tmd.ac.jp

Circulation
|July 30, 2008
PubMed
まとめ

ディスリピデミアのアポリプロテインCIII (apoCIII) は,タンパク質キナーゼC-β (PKCbeta) を活性化することによって,血管内皮細胞におけるインスリンシグナル伝達を損なう. これは,内皮機能障害と窒素酸化物産生の減少につながり,動脈硬化に寄与します.

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