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Updated: Jul 3, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
07:20

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents

Published on: May 28, 2014

プラテンシンの適当な非対称合成

K C Nicolaou1, Qiao-Yan Toh, David Y-K Chen

  • 1Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (ASTAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667. kcn@scripps.edu

Journal of the American Chemical Society
|July 31, 2008
PubMed
まとめ

研究者らは,プラテンシンの重要な構成要素であるエノン3の簡潔で効率的な合成を開発した. この方法は,分子内ダイエルス・アルダー反応を用いて,プラテンシンの全合成を効率化しています.

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関連する概念動画

Preparation of 1° Amines: Gabriel Synthesis01:28

Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...