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Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Operon Model01:23

Operon Model

The operon model represents a fundamental mechanism of gene regulation in prokaryotes, enabling coordinated expression of genes involved in related metabolic or functional pathways. Operons consist of structural genes, a promoter, and an operator, with transcription regulated by repressors, activators, and small effector molecules.Structure and Function of OperonsAn operon is a cluster of structural genes transcribed together under the control of a single promoter. The promoter region...

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関連する実験動画

Updated: May 13, 2026

The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 15, 2013

ダイナミックに変化する環境における代謝遺伝子調節

Matthew R Bennett1, Wyming Lee Pang, Natalie A Ostroff

  • 1Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA.

Nature
|August 1, 2008
PubMed
まとめ

細胞は環境信号をフィルタリングすることで,環境の変化に適応する. サッカロミセス・セレヴィセア (Saccharomyces cerevisiae) とは,この種の植物である.

科学分野:

  • 細胞の適応 細胞の適応
  • 遺伝子規制ネットワークとは
  • メタボリックシステム生物学 メタボリックシステム生物学

背景:

  • 細胞は,生き延びるために,ダイナミックな環境に適応しなければなりません.
  • 遺伝子調節ネットワークは,環境変化に対する細胞の反応を制御する.
  • 細胞の適応を理解するには,ダイナミックな環境シミュレーションが必要です.

研究 の 目的:

  • ダイナミックな環境条件下でSaccharomyces cerevisiaeの代謝遺伝子調節を調査する.
  • 炭素源の周期的な変化に細胞がどのように反応するかを決定する.
  • 異なる酵母菌株の周波数応答を比較する.

主な方法:

  • ダイナミックな環境条件の正確な制御のためにマイクロ流体プラットフォームを使用しました.
  • Saccharomyces cerevisiaeのメタボリック遺伝子調節をモニターした.
  • 実験結果を予測し,比較するために計算モデリングを使用した.

主要な成果:

  • 代謝システムは低通路フィルターとして機能し,環境の変化に反応し,急速な変動を無視します.
  • 炭素源に依存するトランスクリプト半減期に起因する予測より速い低周波応答が観察されました.

さらに関連する動画

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

関連する実験動画

Last Updated: May 13, 2026

The Use of Chemostats in Microbial Systems Biology
13:19

The Use of Chemostats in Microbial Systems Biology

Published on: October 15, 2013

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast
06:53

In Vivo Monitoring of Transcriptional Activity During Metabolic Transition Using a Bioluminescent Reporter in Yeast

Published on: February 21, 2025

  • 異なる誘導特性を持つ酵母菌株の間で保存周波数応答を特定した.

    • 結論:

    • Saccharomyces cerevisiaeの代謝ネットワークは,ダイナミックな環境に対する強固な反応に最適化されています.
    • トランスクリプト半減期の変動性は,細胞適応の正確なモデリングに不可欠です.
    • セルラーシステムは,静的なネットワーク特性の変動にもかかわらず,最適化されたダイナミックな応答を示します.