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Updated: Jul 3, 2026

A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells
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A Reporter Assay to Analyze Intronic microRNA Maturation in Mammalian Cells

Published on: June 16, 2022

異質リボヌクレオプロテインによるCD45の代替スプライシングの規制, hnRNPLLL, hnRNPLL

Shalini Oberdoerffer1, Luis Ferreira Moita, Daniel Neems

  • 1Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.

Science (New York, N.Y.)
|August 2, 2008
PubMed
まとめ

異質リボヌクレオプロテインL型 (hnRNPLL) は,T細胞におけるCD45の代替スプライシングを調節する. このタンパク質は,T細胞の活性化,増殖,生存に不可欠であり,CD45の代替スプライシングに影響を与えます.

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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