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Updated: Feb 7, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
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ストライアタルシナプス可塑性の二極ドーパミン作用制御

Weixing Shen1, Marc Flajolet, Paul Greengard

  • 1Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Science (New York, N.Y.)
|August 9, 2008
PubMed
まとめ

中等脊髄ニューロン (MSN) のドーパミン (DA) 受容体は,学習に不可欠な双方向シナプス可塑性を可能にします. パーキンソン病はパーキンソン病です.

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Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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It is essential to understand how structural members behave under plastic deformation when the bending stress exceeds the material's yield strength. This state of deformation permanently alters the shape of the member, in contrast to the linear elastic behavior observed before yielding. The strain at any point in the member is expressed in terms of maximum strain. Notably, the neutral axis, which coincides with the centroid during elastic bending, shifts away from the centroid under plastic...
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