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An Application for Pairing with Wearable Devices to Monitor Personal Health Status06:58

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The present protocol introduces a non-commercial self-developed application for collecting real-time on-site data, including psychological scales, GPS location, heart rate, and blood-oxygen saturation level, as well as the application's operating procedures. An empirical study conducted in Taiwan in 2020 was used as an application...
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Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack07:31

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We demonstrate how to deploy a real-time psychosis risk calculation and alerting system based on CogStack, an information retrieval and extraction platform for electronic health...
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The goal of this protocol is to enable non-dental professionals to assess oral health status for research or health-screening purposes. Aspects assessed include lips, tongue, soft and hard tissues, natural and artificial teeth, oral cleanliness, plaque, swallowing, and impact of oral health on quality of...
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Necropsy-based Wild Fish Health Assessment07:57

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The health of wild fishes can be used as an indicator of aquatic ecosystem health. Necropsy-based fish health assessments provide documentation of visible lesions or abnormalities, data used to calculate condition indices as well as the opportunity to collect tissues for microscopic evaluation, gene expression and other more in-depth...
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Biomarkers are directly-measured biological indicators of disease or health. In population and social sciences, biomarkers need to be easy to obtain, transport, and analyze. Dried Blood Spot (DBS) collection meets this need, can be collected in the field with high response rates and analyzed for a variety of...
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We demonstrate the utility of nest building behavior in laboratory mice as an indicator of welfare. Nest scoring is a sensitive technique that is altered by temperature, illness, and aggression. The time to integrate into nest test (TINT) is a simple cage-side assessment that can detect postoperative...
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Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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疾患特有の誘発性多能性幹細胞を誘発した.

In-Hyun Park1, Natasha Arora, Hongguang Huo

  • 1Department of Medicine, Division of Pediatric Hematology Oncology, Children's Hospital Boston, and Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Cell
|August 12, 2008
PubMed
まとめ
この要約は機械生成です。

研究者らは,様々な遺伝疾患を患っている患者の誘発性多能幹細胞 (iPS) を生成した. これらの患者特有の幹細胞は,研究と薬剤開発のためにヒト疾患のインビトロモデリングを可能にします.

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科学分野:

  • 幹細胞生物学 幹細胞生物学とは
  • 遺伝学 遺伝学とは
  • 医学研究 医学研究

背景:

  • 患者由来細胞の組織培養は,医学研究において極めて重要です.
  • 現在の資源は,腫瘍細胞系または変形した組織に限られています.
  • 遺伝病に対する患者特有の多様な細胞モデルが必要である.

研究 の 目的:

  • 誘発性多能幹細胞 (iPS) を,さまざまな遺伝疾患を患っている患者から生成する.
  • 疾患特有の幹細胞の資源をインビトロ疾患モデリングのために確立する.
  • 遺伝疾患に対する調査と薬の開発を容易にする.

主な方法:

  • 患者の体細胞から誘発性多能幹細胞 (iPS) の生成.
  • 再プログラミング技術を活用して多能性を達成する.
  • 様々な遺伝疾患の背景から派生したiPS細胞の特徴.

主要な成果:

  • メンデルの病や複雑な遺伝疾患を患っている患者のiPS細胞を成功裏に生成した.
  • 重症複合免疫不全症,筋縮症,パーキンソン病,糖尿病などの疾患が含まれていました.
  • 患者から得られた,疾患特有の多能幹細胞のコレクションを確立しました.

結論:

  • 患者から誘発された多能幹細胞は,ヒトの病気を研究する強力なツールである.
  • これらの疾患特異性幹細胞は,正常および病的な組織形成の復元を可能にします.
  • このリソースは,病気の調査と治療の開発を進めるために貴重なものです.