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Updated: Jul 2, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

p53の標的遺伝子であるセストリン1とセストリン2は,遺伝子毒性ストレスとmTORシグナル伝達とを結びつける

Andrei V Budanov1, Michael Karin

  • 1Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, MC0723, La Jolla, CA 92093, USA.

Cell
|August 12, 2008
PubMed
まとめ

ストレスによって活性化された腫瘍抑制剤p53は,mTOR信号伝達を抑制するためにセストリンを使用します. この研究は,p53がAMPK-TSC2-mTOR経路経由で細胞成長を制御する方法を明らかにし,がん研究における重要なリンクを明らかにしています.

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Purification of Ubiquitinated p53 Proteins from Mammalian Cells

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