関連する実験動画

Updated: Jul 2, 2026

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

移行状態の仮想スクリーニングによって設計された最も効率的なコカインヒドローラゼ

Fang Zheng1, Wenchao Yang, Mei-Chuan Ko

  • 1Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 725 Rose Street, Lexington, Kentucky 40536, USA.

Journal of the American Chemical Society
|August 20, 2008
PubMed
まとめ

科学者たちは,コカインを素早く代謝するために,高効率のヒトブチリルコリネステラーゼ (BChE) 酵素変異体を設計しました. この画期的な発見は,コカイン依存症と過剰摂取の治療のための新たな治療戦略を提示する可能性がある.

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...