米国成人のアルゼンチンの暴露と2型糖尿病の罹患率

Ana Navas-Acien¹, Ellen K Silbergeld, Roberto Pastor-Barriuso

¹Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room W7033B, Baltimore, MD 21205, USA. anavas@jhsph.edu

JAMA

|August 21, 2008

まとめ

尿中のアルセンの総量は,米国の成人の2型糖尿病のより高い罹患率と関連していました. これは,無機アルゼンチンの曝露が糖尿病に寄与する可能性があることを示唆し,さらなる調査を正当化しています.

科学分野:

環境衛生環境衛生環境衛生
エンドクリノロジーエンドクリノロジー
毒理学毒理学毒理学

背景:

高度な慢性無機ヒ素暴露は糖尿病と関連しています.
糖尿病のリスクに対する低度から中度までの無機ヒ素暴露の影響は不明である.
魚介類からのアルセノベタインは,無毒であると考えられています.

研究の目的:

尿中のヒ素濃度と2型糖尿病の罹患率との関連を調べる.
研究は,米国の成人の代表的なサンプルに焦点を当てた.

主な方法:

2003~2004年のNHANES.より20歳以上の788人の成人を対象とした横断研究.
尿中のヒ素濃度 (総量,ディメチルアルシネート,アルセンベタイン) を測定した.
2型糖尿病の罹患率は,ヒ素摂取量全体で評価されました.

主要な成果:

2型糖尿病の参加者は,尿中のアルゼン濃度が合計で26%高かった.
2型糖尿病の確率は,アルゼンとディメチルルシネートの総濃度が高くなるにつれて著しく増加しました.
2型糖尿病と2型糖尿病のない参加者の間でアルセノベタインのレベルは違わなかった.

結論:

尿中のアルセンは,低暴露レベルでも,2型糖尿病の罹患率の増加と関連しています.
発見は,飲料水中の無機ヒ素が糖尿病の流行に寄与する可能性があるという仮説を裏付けている.
原因関係を確認するためにさらなる見通し研究が必要である.

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