ニューロサイコロジカルテストの変異性およびインシデント認知症のインサイド・パーソン・クロス・クロス・変異性
Roee Holtzer1, Joe Verghese, Cuiling Wang
1Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA. rholtzer@aecom.yu.edu
JAMA
|August 21, 2008
まとめ
神経心理学的テストのパフォーマンスの変動性は,認知症を予測します. 個別テストのスコアに関係なく,個体内のテストの変動性の高さは,認知症のリスクの増加と関連しています. この発見は,認知症の予測モデルを改善します.
科学分野:
- ゲロントロジーはゲロントロジーの学科です.
- 神経学 神経学とは
- サイコメトリクス サイコメトリクス
背景:
- 神経心理学的検査は,認知症の予測と診断のための標準的なツールです.
- 以前の研究では,認知症の神経心理学的テストにおける個体内変動の予測的価値を調査していなかった.
研究 の 目的:
- 神経心理学的テストにおける個人の内部の変動が,将来の認知症の発症を予測するかどうかを判断する.
主な方法:
- 70歳以上の897人の参加者を含む人口ベースの縦断研究 (アインシュタインエイジング研究)
- コックス比例リスクモデルが,インシデント認知症のリスク比率を評価するために使用されました.
- 個別テスト (例えば,FCSRT,DSST,Vocabulary) のパフォーマンスを分析し,個人内テストの可変性.
- 性別によって分層化され,教育と医学的な病気のために制御された分析.
主要な成果:
- 神経心理学的テストにおける個体内変動性の増加は,インシデント認知症 (HR=3.93) と有意に関連していました.
- この関連性は,個々のテストのパフォーマンス (HR=2.10) を調整した後でも有意のままでした.
- テストの変動性を含めると,認知症の予測モデルと1年間の感度が改善されました.
結論:
- 神経心理学的テストのパフォーマンスにおける個人の内部の変動性は,認知症の独立した予測因子です.
- この測定は,従来の個々のテストスコアを超えて,認知症リスクの予測を強化します.
- これらの発見を確認するためにさらなる研究が必要である.
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