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CDKは,DNA末端切除と同類復合を制御するためにSae2をターゲットにしています

Pablo Huertas1, Felipe Cortés-Ledesma, Alessandro A Sartori

  • 1The Wellcome Trust and Cancer Research UK Gurdon Institute, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Nature
|August 22, 2008
PubMed
まとめ

DNA修復の細胞サイクル制御は,サイクリン依存キナーゼ (CDK) によって管理され,Sae2タンパク質をリン酸化し,正確な同類再結合 (HR) 修復のためにDNA二重鎖破裂 (DSB) 切除を調節します.

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