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Updated: May 29, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
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Published on: March 31, 2015

ALKを主要な家族性ニューロブラストーマ予備性遺伝子として特定した

Yaël P Mossé1, Marci Laudenslager, Luca Longo

  • 1Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Nature
|August 30, 2008
PubMed
まとめ

アナプラスティックリンパ腫キナーゼ (ALK) 遺伝子の生殖系統変異は,遺伝性ニューロブラストーマの主要な原因です. 遺伝的および獲得的の両方のALK変異を活性化することは,この小児がんの潜在的な治療目標です.

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