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Assembly of Complex Microtubule Structures
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ドロソフィラの性対称性特性を制御する遺伝子スイッチの調節と進化
Thomas M Williams1, Jane E Selegue, Thomas Werner
1Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA.
Cell
|August 30, 2008
まとめ
研究者らは,果物ハエの男性特有の腹部染色体を制御する遺伝子スイッチを発見した. これは,Bric-à-brac (Bab) 遺伝子発現を調節するHOXタンパク質Abdominal-B (ABD-B) とDoublesex (DSX) を含み,性二型特性の進化の洞察を明らかにしています.
科学分野:
- 進化的発達生物学 進化的発達生物学
- 遺伝学 遺伝学とは
- 動物の行動 動物の行動
背景:
- 性二形態の特徴は,動物の進化と行動に不可欠ですが,その発達メカニズムはほとんど不明のままです.
- ドロソフィラ・メラノガスターの雄性特有の腹部色素は,最近進化した二形特質であり,Bric-à-brac (Bab) タンパク質によってメスに抑制されます.
研究 の 目的:
- ドロソフィラ・メラロノガスター (Drosophila melanogaster. melanogaster. Drosophila melanogaster. melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster. Drosophila melanogaster.
主な方法:
- ディモルフなバブ発現を制御するシス調節要素 (CRE) の識別と進化の追跡.
- HOXタンパク質のAbdominal-B (ABD-B) および性特異のDoublesex (DSX) アイソフォームによるbab CREの直接調節の分析.
主要な成果:
- HOXタンパク質のAbdominal-B (ABD-B) と性特異のDoublesex (DSX) の同型は,バブシス調節要素 (CRE) を直接調節する.
- 女性では,ABD-BとDSX(F) がバブ発現を活性化しますが,男性では,DSX(M) がバブを直接抑制し,色素化を可能にします.
- 変形性バブ発現の進化には,他の変形性特性を祖先によって調節したCREの微細な変化が伴いました.
結論:
- 既存の二形特性を支配する遺伝ネットワーク内の改変から,新しい性二形特性が生じることがあります.
- この研究は,果物ハエの特定の二形特性の進化の基礎となる複雑な遺伝的調節を明らかにしています.
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