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An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice
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An Improved Method for Collection of Cerebrospinal Fluid from Anesthetized Mice

Published on: March 19, 2018

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ヒストン脱エチラゼ2のS-ニトロシル化により,神経細胞におけるクロマチンの改造が誘発される

Alexi Nott1, P Marc Watson, James D Robinson

  • 1MRC Laboratory for Molecular and Cell Biology, and Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.

Nature
|August 30, 2008
PubMed
まとめ

脳由来神経栄養素因子 (BDNF) は,酸化窒素 (NO) の合成を誘発し,ヒストン脱酸化酵素2 (HDAC2) のS-ニトロシル化につながります. このプロセスは,染色体からHDAC2を放出し,神経細胞の発達と可塑性にとって重要な遺伝子の活性化を促します.

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