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Updated: Jul 2, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Published on: February 6, 2019

(6-4) 光解酶メカニズムがオクセタン中間体を通して進行できる証拠

Saâdia Asgatay1, Christian Petermann, Dominique Harakat

  • 1Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 6229, UFR de Pharmacie, 51 rue Cognacq-Jay, 51096 Reims Cedex, France.

Journal of the American Chemical Society
|September 4, 2008
PubMed
まとめ

研究者は,DNA修復を調査するために,修飾されたチミンダイマー (Tpm3T) を使用しました. 彼らは,オクセタン中間体への水添加がそれを開くことを発見し,オクセタン中間体を含む (6-4) 光解酶修復経路の証拠を提供しました.

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The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
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