スタチンとナイアシンを併用した治療は,高密度リポタンパク質プロテオームを再構成します

Pattie S Green¹, Tomas Vaisar, Subramaniam Pennathur

¹Department of Medicine, University of Washington, Seattle, WA, USA. psgreen@u.washington.edu

Circulation

|September 4, 2008

まとめ

スタチンとナイアシンの併用療法により,冠動脈疾患患者の高密度リポプロテイン (HDL) タンパク質組成が改善されました. この治療はHDLタンパク質の変化を部分的に逆転させ,健康な個人に似ていた.

科学分野:

心血管疾患に関する研究
脂質代謝脂質代謝とは
プロテオミクスプロテオミクスは,プロテオミクスの

背景:

低高密度脂質タンパク質 (HDL) レベルは,心血管疾患の予防のターゲットです.
冠動脈疾患 (CAD) の患者では,アポリポプロテインEの濃縮と変異したタンパク質の負荷を示しています.
HDLタンパク質の組成の変化は,その抗アテロゲン性および抗炎症的機能に影響を与える可能性があります.

研究の目的:

HDLレベルを上昇させるスタチンとナイアシンを併用した治療が,CAD患者の変化したHDLタンパク質組成を逆転させることができるかどうかを調査する.
この組み合わせ療法によって,HDLプロテオームが,健康な個体で見られる状態に正常化するかどうかを判断する.

主な方法:

液体染色体-フーリエ変換-質量スペクトロメトリーを用いたHDL(3) タンパク質組成の分析,併用療法1年前のおよび後のCAD被験者.
タンパク質の変異をスペクトル計数と抽出イオン染色体で定量化する.
CAD患者の別のコホートにおけるアポリポプロテインEレベル変化の生化学的検証.

主要な成果:

併用療法により,HDLにおけるアポリポプロテインEの濃度が有意に低下した.
治療は,コレステロールの逆輸送に関与するマクロファージタンパク質の豊富さを増加させた.
治療を受けたCAD被験者のHDL(3) プロテオームは,健康な対照群のそれとより密接に似ていた.

結論:

スタチンとナイアシンを併用した治療は,冠動脈疾患における異常なHDL (3) タンパク質組成を部分的に逆転させます.
HDLプロテオームの測定は,動脈硬化症の予防を目的とした治療法の有効性についての洞察を提供します.

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