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Updated: May 5, 2026

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes
09:40

Co-immunoprecipitation Assay for Studying Functional Interactions Between Receptors and Enzymes

Published on: September 28, 2018

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SH2-キナーゼドメインの構造的結合は,FesとAbl基板の認識とキナーゼ活性化をリンクします

Panagis Filippakopoulos1, Michael Kofler, Oliver Hantschel

  • 1Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.

Cell
|September 9, 2008
PubMed
まとめ

FesとAblチロシンキナーゼのSH2ドメインは,キナーゼドメインと相互作用することによってシグナル伝達を強化します. この構造的統合は,これらのプロ腫瘍性キナーゼのキナーゼ活性化と基板認識に不可欠です.

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