冠動脈疾患の患者におけるSTセグメントうつ病の危険因子としての粒子状大気汚染
Kai Jen Chuang1, Brent A Coull, Antonella Zanobetti
1Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA.
Circulation
|September 10, 2008
まとめ
微細粒子物質 (PM2.5) とブラックカーボンによる大気汚染物質への曝露は,心臓病患者のSTセグメントうつ病と関連しています. このリスクは,最近心筋梗塞の損傷を受けた人,特にイベント後の最初の1ヶ月以内に増加します.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 心臓病学 心臓病学
- エピデミオロジー エピデミオロジー
背景:
- 粒子状物質 (PM) 曝露は,心血管疾患の既知の危険因子です.
- PM誘発性イシュケミアは,汚染と心疾患の有害事象を結びつける疑われるメカニズムである.
研究 の 目的:
- 心臓病患者の環境大気汚染とSTセグメントの変化との関連を調査する.
- 特定の汚染物質とリスクの高い患者のサブグループを特定する.
主な方法:
- 48人の心臓病患者を対象に,1年間までモニタリングした繰り返し測定試験です.
- 24時間ホルター心電図モニタリングにより,STセグメントのレベルが測定され,周囲のPM2.5とブラックカーボンレベルと相関しています.
- 分析には,心筋梗塞,急性冠動脈症候群,または安定した冠動脈疾患を有する患者が含まれていました.
主要な成果:
- 高い微細粒子物質 (PM2.5) とブラックカーボンレベルは,STセグメントのうつ状態を予測した.
- ブラックカーボン曝露の増加とSTセグメントのうつ状態との間に有意な関連性が見つかりました.
- 効果は,最近心筋梗塞または糖尿病を患った患者および入院後最初の1ヶ月以内により顕著でした.
結論:
- 心臓病患者のSTセグメントうつ病は,PM2.5とブラックカーボンへの曝露と関連しています.
- 汚染に関連したSTセグメントうつ病のリスクは,最近心筋損傷を受けた患者,特に心筋損傷後の最初の1ヶ月以内に上昇します.
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