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Updated: Jul 1, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

型IV粘脂症に関連したタンパク質TRPML1は,エンドリソソームの鉄放出チャネルである

Xian-Ping Dong1, Xiping Cheng, Eric Mills

  • 1The Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, 3089 Natural Science Building (Kraus), 830 North University, Ann Arbor, Michigan 48109, USA.

Nature
|September 17, 2008
PubMed
まとめ

トランジエント受容体潜在性ムコロリピン1 (TRPML1) は,後期エンドソームとリソソームにおけるFe2+) チャンネルとして作用する. TRPML1の機能を損なう変異は,鉄代謝に影響することで,粘脂症型IV疾患の症状に寄与する.

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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

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