関連する実験動画
Updated: Jul 1, 2026
04:07
Isolation of Epithelial Cells from Human Dental Follicle
Published on: November 5, 2021
脊椎動物の口腔歯の二重の表 epithelial 起源は,脊椎動物による口腔歯の二重の表 epithelial 起源は,脊椎動物による口腔歯の二重の表 epithelial 起源は,脊椎動物による口腔歯の二重の表 epithelial
Vladimír Soukup1, Hans-Henning Epperlein, Ivan Horácek
1Department of Zoology, Charles University in Prague, Vinicna 7, 128 44 Prague, Czech Republic.
Nature
|September 17, 2008
まとめ
アクソロットルの研究は,口腔の歯は,外皮と内皮の両方から発達することが可能であることを明らかにし,以前の理論に挑戦しています. これは,上皮の起源に関係なく,神経の細胞が歯の進化に重要な役割を果たしていることを示唆しています.
科学分野:
- 発達生物学 発達生物学とは
- 進化生物学の進化生物学について
- 脊椎動物の古生物学について
背景:
- 脊椎動物の口腔は,通常,外皮内膜から形成されます.
- 口腔の歯は,伝統的に,エクトダーム (エナメル) とニューラル・クライスト・メゼンキーム (デンティン,パルプ) からのみ発生すると信じられていた.
- 口腔の外に広がる歯の起源は不明であり,潜在的に外皮または内皮から発生する可能性がある.
研究 の 目的:
- 脊椎動物における口腔歯の胚的起源を調査し,特に外皮および内皮の貢献を調べる.
- 耳鼻膜の崩壊後の細胞の発達可能性を明らかにする.
- 歯の発達の進化的影響を理解し,神経頂上細胞の役割に焦点を当てます.
主な方法:
- 詳細な運命マッピング研究のために,トランスジェニックのアクソロットルを利用しました.
- 歯の発達中に細胞系統を追跡するために,実験的アプローチの組み合わせを使用しました.
- 口腔歯の胚性源を分析し,エナメルエピテリア,デンチン,およびパルプを含む.
主要な成果:
- アクソロトルの口腔歯は,外皮と内皮の両方から派生できるという証拠を提供した.
- 外皮/内皮の起源が混じった歯の存在を証明した.
- 口内歯の発達の一致性は,エナメル表皮の胚的起源が異なるにもかかわらず観察されました.
結論:
- ニューラル・クライスト・メゼンキームは,歯の開始に優位な役割を果たしているようで,上皮質の起源を優先する.
- ニューラル・クライスト細胞のオドントジェニック能力は,歯の進化の重要な要因である.
- 歯の進化は,表 epithelial 源に関係なく,神経の能力によって駆動されている可能性があります ('outside-in' vs. 'inside-out').
関連する概念動画
01:21Tooth Anatomy
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
01:15Teeth
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
01:11Oral Cavity
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Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
01:56Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
01:30Neurulation
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...
01:10Zygotic Development And Stem Cell Formation
The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...