尿中のビスフェノールA濃度と,成人における医学的な疾患および検査異常との関連
Iain A Lang1, Tamara S Galloway, Alan Scarlett
1Epidemiology and Public Health Group, Peninsula Medical School, Barrack Rd, Exeter EX2 5DW, UK.
JAMA
|September 19, 2008
まとめ
尿中のビスフェノールA (BPA) 濃度の上昇は,成人における心血管疾患と糖尿病のリスクの増加と関連しています. この一般的な化学物質への曝露は,一般の人々の予防可能な健康問題に寄与する可能性があります.
科学分野:
- 環境衛生 環境衛生 環境衛生
- 毒理学 毒理学 毒理学
- 公衆衛生は公衆衛生である.
背景:
- ビスフェノールA (BPA) は,食品および飲料用容器で使用されるエポキシ樹脂に含まれる至るところに存在する化学物質です.
- 動物の研究は有害効果を示唆し,慢性的な低レベルの人間の暴露に関する懸念を高めています.
研究 の 目的:
- 尿中のBPA濃度と米国の成人の健康状態との関連を調査する.
- BPA暴露と慢性疾患および代謝マーカーとの潜在的な関連を特定する.
主な方法:
- 2003~2004年の国家健康栄養調査から1455人の成年者 (18~74歳) の横断分析.
- 尿中のBPAとクレアチニンの濃度が測定され,リグレッションモデルは複数の人口統計および健康要因に調整されました.
- 慢性疾患の診断と肝機能,グルコースホメオスタシス,炎症,脂質の血液マーカーとの関連が評価されています.
主要な成果:
- 尿中のBPA濃度の上昇は,心血管疾患の診断と有意に関連していた (OR=1.39,P=.001).
- また,BPA濃度の上昇は,糖尿病の罹患率の上昇と関連していた (OR=1.39,P<.001).
- 肝臓酵素:ガンマ-グルタミルトランスフェラーゼ (OR=1.29,P<.001) とアルカリリンフォスファターゼ (OR=1.48,P=.002) の異常レベルとの関連が観察されました.
結論:
- 尿中のBPA濃度の上昇によって示されるBPAの露出の増加は,成人集団における予防可能な発病率と関連している可能性があります.
- 研究結果は,BPAが慢性疾患の発症に及ぼす公衆衛生上の潜在的な影響を示唆しています.
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