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Updated: May 5, 2026

Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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クリン-RINGリンガゼのNEDD8活性化に関する構造的洞察:結合の構成制御

David M Duda1, Laura A Borg, Daniel C Scott

  • 1Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

Cell
|September 23, 2008
PubMed
まとめ

Cullin-RINGリガゼ (CRLs) の活動は,NEDD8の修正によって制御されています. この構造の変化は,不活性な形態を不利にし,ポリユビキチン化を促進し,CRLの機能を強化します.

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