喘息における薬物開発の新たなターゲット
Ian M Adcock1, Gaetano Caramori, K Fan Chung
1Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK.
Lancet (London, England)
|September 23, 2008
まとめ
喘息は世界中で3億人に影響し,5-10%が重症で治療が難しい病気である. 将来の治療法は,パーソナライズされた喘息管理のための特定の炎症経路をターゲットにします.
科学分野:
- 肺内科 肺内科 肺内科
- 免疫学 免疫学とは
- 薬理学 薬理学とは
背景:
- 喘息は慢性呼吸道炎症性疾患で,世界中で3億人が罹患しており,増加すると予測されています.
- ほとんどの患者は,吸入用コルチコステロイドやベータアゴニストに反応しますが,5-10%は重症で耐性喘息を持っています.
- 喘息のフェノタイプを理解するうえでの進歩は,異なる炎症的プロフィールを明らかにし,抗ルクトリエンおよびオマリズマブなどの標的型治療を導く.
研究 の 目的:
- 喘息の病理生理学と炎症メカニズムに関する現在の知識をレビューする.
- 特定の経路とメディエーターを対象とした新興の治療戦略について議論する.
- 重度の喘息治療におけるパーソナライズド医療の可能性を調査する.
主な方法:
- 喘息の病理生理学,現象型,治療の進歩に関する文献レビュー.
- 現在の治療薬および試験中の治療薬の分析.
- 喘息研究と臨床管理における将来の方向性についての議論.
主要な成果:
- 特定の炎症タイプに関連した異なる喘息のフェノタイプを認識する.
- p38 MAPK,抗酸化物質,IL-13,免疫調節細胞を含む新しい治療標的の特定.
- 重度の喘息におけるコルチコステロイド無感性を克服するための組み合わせ療法の可能性.
結論:
- 呼吸道炎症メカニズムに関するさらなる研究は,改善された喘息治療のために不可欠です.
- 標的型療法と組み合わせた治療法の開発は,重度の喘息の管理に有望である.
- 異なる喘息サブタイプに基づいたパーソナライズされた治療戦略は,治癒は遠いものの,将来の目標です.
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