トランスムラル心筋のストレンの変化:ミトラル吐における左心室機能不全の早期マーカー?
Carl J Carlhäll1, Tom C Nguyen, Akinobu Itoh
1Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305-5247, USA.
Circulation
|October 10, 2008
まとめ
左心室 (LV) 経口筋の変化は,重度のミトラル反発 (MR) の早期のLV機能不全を示唆する可能性があります. この研究では,羊のモデルで菌株の変異が発見され,外科的なタイミングの潜在的な新しいマーカーを示唆しました.
科学分野:
- 心臓病学 心臓病学
- バイオメディカルエンジニアリング
- 動物モデル 動物モデル
背景:
- 重度の単離性ミトラル反発 (MR) は,左心室 (LV) 機能不全につながる可能性があります.
- LV機能障害の早期発見は,無症状の患者の間に適切な外科介入に不可欠です.
- 現在のマーカーは,早期の機能的変化を十分に捉えることができないかもしれません.
研究 の 目的:
- 慢性MRモデルにおいて,LVのトランスムラル筋動脈株の変化が,LV機能不全の早期マーカーとして機能するかどうかを調査する.
- 菌株の変化をBNP,PRSW,tauなどの既定のマーカーと比較する.
主な方法:
- 慢性的な純粋MRのオブインモデルが,後部部ミトラレフレット穿孔を誘導することによって作成されました.
- 3Dトランスムラル菌株は,手術後1週目と12週目に,X線写真でLV壁に挿入されたビーズセットを使用して測定されました.
- LV再構成と機能は,LV質量,LVEDVI,BNP,PRSW,tauによって評価されました.
主要な成果:
- MRモデルは,対照群と比較して12週後にLV質量およびLVEDVIの増加を示した.
- グループ間のBNP,PRSW,またはtauの変化において有意な差異は観察されなかった.
- 12週目にMR群の下腸内臓で,縦横のダイアストリック充填株の有意な変化が検出されました.
結論:
- 慢性的な純粋MRは,外側筋膜の改造と,トランスムラル筋膜のストレートによって検出可能な早期の機能的変化を誘発する.
- このモデルでは,トランスムラル筋動脈のストレンス変異は,BNP,PRSW,またはtauよりも,LV機能障害のより敏感な早期指標であるようです.
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