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Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites
Published on: January 4, 2011
類人猿とヒトのマラリア寄生虫プラズモジアのゲノムが知られています
1Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. ap2@sanger.ac.uk
Nature
|October 10, 2008
まとめ
Plasmodium knowlesiのゲノムは,他のPlasmodium種とは異なり,分散した変異抗原遺伝子を明らかにしています. この猿はマラリアの寄生虫である.
科学分野:
- マラリア学 マラリア学
- ゲノミクスゲノミクスとは
- 寄生虫学とは,寄生虫学である.
背景:
- プラズモディウムノウレセシ (Plasmodium knowlesi) は,マラリアの寄生虫であるサルで,東南アジアでは人への感染が増加している.
- プラズモディウム・ビバックスと系統遺伝的関係を共有しているが,特徴的な現象特性を有している.
- 抗原的変異は最初にプラズモディウムノウレセシで示された.
研究 の 目的:
- Plasmodium knowlesi (H株,Pk1(A+) クローン) の核ゲノム配列解析を提示する.
- Plasmodium vivaxや他のPlasmodium種との比較ゲノミクスを可能にするために.
- P. knowlesi. の抗原変異のゲノム基盤を調査する.
主な方法:
- プラズモディアムノウレシ (H株,Pk1(A+) クローン) の全ゲノム配列決定.
- 核ゲノム配列のバイオ情報分析.
- 他のプラズモディアム種との比較ゲノム分析.
主要な成果:
- これは,サルマラリア寄生虫のゲノム配列が初めて記述されたものです.
- 推定変異抗原ファミリーは,P. knowlesiのゲノム全体に分散しており,テロメアの繰り返しに関連しています.
- 変異抗原のKIRファミリーは,宿主CD99の細胞外ドメインとの配列ホモロジーを示し,分子模倣を示唆しています.
結論:
- P. knowlesiのゲノムは,他のPlasmodium種との比較研究のための貴重なリソースを提供します.
- P. knowlesiの変異抗原ファミリーのゲノム組織は,他のプラズモディウム種とは著しく異なる.
- KIR配列によって示唆される分子ミミクリは,プラズモディウムノウレレシスにおける新たな免疫回避戦略を代表する可能性がある.
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