喫煙者の赤ちゃんや早産の赤ちゃんにおける心血管ストレス過反応性
Gary Cohen1, Silvano Vella, Heather Jeffery
1Department of Women and Child Health, Neonatal Unit, Karolinska Institute, Elevhemmet H1-02, S-171 76 Stockholm, Sweden. Gary.Cohen@kbh.ki.se
Circulation
|October 15, 2008
まとめ
胎児の早産や母親の喫煙に曝された乳児は,心臓血管の反応性が高まり,将来の心臓疾患の早期プログラム化の可能性を示しています. この静かな機能障害は,高血圧などの疾患のリスクを増やす可能性があります.
科学分野:
- 産経周りの健康についてです.
- 心血管の生理学 心血管の生理学
- 開発のためのプログラミング
背景:
- 胎児の早産,低出生体重,母親の喫煙は,妊娠中期の重大な合併症である.
- これらの要因は,後年における心血管機能不全に対する感受性の増加と関連しています.
- 心血管機能障害の早期マーカーを特定することは,公衆衛生にとって極めて重要です.
研究 の 目的:
- 心血管機能障害の初期"静かな"プログラミングを調査する.
- 副産後有害事象を経験した乳児の心血管反応性を評価する.
- 心血管リスクの早期の指標を特定する.
主な方法:
- 3つの乳児群の心血管反応を比較した:コントロール群,早産児,そして母が喫煙した乳児.
- 4%の二酸化炭素 (CO2) の呼吸と被動的な頭上傾き (60度) の2つの通常のストレステストを使用しました.
- 妊娠後40~42週間の睡眠中に測定された血圧 (BP) と心拍数.
主要な成果:
- 喫煙者の赤ちゃんは,対照群と比較して,CO2に対する高血圧と心拍数反応を示した.
- 胎児は予想される高血圧でしたが,CO2に対する心拍数反応はありませんでした.
- 胎児とタバコに曝された乳児は,対照群と比較して,ヘッド・アップ・ティルト時に血圧が3〜4倍上昇した.
結論:
- 血管,心臓,血圧の反応性の上昇は,早産の乳児や喫煙者の乳児で観察されています.
- この発見は,心血管機能不全の胎児内および出産後の早期"プログラミング"の概念を裏付けている.
- この早期の機能不全は,高血圧や突然の乳児死亡症候群を含む後期の合併症として表れることがあります.
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