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Updated: Mar 31, 2026

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
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Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

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遺伝子ポジショニングの意味

Takumi Takizawa1, Karen J Meaburn, Tom Misteli

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|October 16, 2008
PubMed
まとめ

ゲノムは核内で非ランダムに編成されています. このエッセイでは,空間的遺伝子位置づけの機能的関連性と,より高い真核生物における遺伝子活動との関連性を探求します.

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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