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Updated: Jul 19, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

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波紋状/Pax-1変異の分子基礎について

G Chalepakis1, R Fritsch, H Fickenscher

  • 1Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Göttingen, Federal Republic of Germany.

Cell
|September 6, 1991
PubMed
まとめ

ペアリングボックス遺伝子Pax-1 (ペアリングボックス遺伝子1) は通常,DNAを結合し,転写を活性化します. 波状のマウスの突然変異は,Pax-1のDNA結合を妨害し,脊柱の異常を説明する.

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Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

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